- Compnay Name:NewEast Biosciences
- Membership: Free Member
- Registration Date:2017.02.17
- Country/Region :United States
- Address :24 Whitewoods Lane, Malvern United States, Malvern
- Phone / Fax :610-945-2007 / 610-945-2008
- Contact:david
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NewEast Biosciences
[United States]
Catalog Number: 26141
Gene Symbol: ATM
Description: Anti-ATM (F858L) Mouse Monoclonal Antibody
Background: Ataxia telangiectasia mutated (ATM) is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis. Activity of ATM protein is under tight control, and mutation of ATM can cause disease such as Ataxia telangiectasia (AT) and cancers.
Immunogen: A synthetic peptide from the internal region of ATM which includes the mutation of F858L, human origin.
Applications: ELISA, WB, IHC
Recommended Dilutions:
ELISA: 1:1000-1:5000
WB: 1:100-1:1000
IHC: 1:50-1:100
Concentration: 1 mg/ml
Host: Mouse
Format: Liquid
Clonality: Monoclonal
Isotype:
Purity: Purified from ascites
Storage buffer:
Preservative: no
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivity: Recognizes ATM (F858L), but not wild type ATM protein from vertebrates.
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